danazol will increase the amount or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
Belzutifan can be a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors may well increase incidence or severity of adverse effects. Check for anemia and hypoxia and decrease belzutifan dose as recommended.
Stay clear of coadministration of delicate CYP3A4 substrates with ivosidenib or substitute with choice therapies. If coadministration is unavoidable, watch clients for lack of therapeutic impact of these prescription drugs.
modafinil will reduce the extent or result of capivasertib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Strong or moderate CYP3A inducers lower capivasertib exposure, which can lessen efficacy.
modafinil will increase the level or result of mavacamten by impacting hepatic enzyme CYP2C19 metabolism. Contraindicated. Strong or moderate CYP2C19 inhibitors may well boost mavacamten systemic exposure, leading to heart failure on account of systolic dysfunction.
Medication that involve prior authorization. This restriction requires that specific clinical criteria be achieved ahead of the acceptance of your prescription.
Observe Closely (1)modafinil will increase levels of eluxadoline by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. To be a precautionary measure because of incomplete information on the metabolism of eluxadoline, use warning when coadministered with robust CYP2C19 inhibitors.
Modafinil was not noticed to market overuse or misuse, even in people who have a historical past of copyright addiction.[124] Regardless of the Preliminary perception that modafinil carried no abuse likely, rising evidence indicates that it works at a similar neurobiological mechanisms as other addictive stimulants.
rifapentine will decrease the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
steroid hormones, such as estradiol, progesterone or cortisol. Modafinil might have an adverse impact on hormonal contraceptives (which include start Management pills, patches, and so on.) for as many as a month right after discontinuation.[142] Each modafinil and armodafinil in America and the uk feature package deal inserts that highlight the conversation amongst these prescription drugs and hormonal birth Management.[ninety five] Modafinil may well induce cytochrome P450 enzymes that happen to be associated with the clearance of steroid hormones taken as hormonal contraceptives, decreasing their performance, which may bring on pregnancy Regardless of using the birth Handle medication.
From time to time, Health professionals will prescribe remedies to help address circumstances that fall outside of the Formal takes advantage of authorized via the FDA — also known as “
When modafinil is made use of as a cognitive enhancer or "intelligent drug" among the healthy people trying to find improved concentration and productivity,[18][19] its use outside the house health-related supervision raises considerations relating to potential misuse or abuse.
acetazolamide will boost the level or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Mysterious.
Ensure you know the way you respond to this drugs before you drive, use machines, or do other Careers that require you to be alert, effectively-coordinated, or ready to think or see click here effectively.